Ophthalmology Division — Ophthalmic Imaging Reading Center

Intrinsic Imaging's Ophthalmology Division provides specialized imaging, functional assessment, and centralized independent review expertise for clinical trials evaluating retinal, macular, optic nerve, and other ophthalmic diseases. Our board-certified ophthalmologists bring extensive clinical research experience, having participated in more than 160 ophthalmology clinical trials as principal investigators or expert reviewers. The Division supports studies across a broad spectrum of ophthalmic indications, including diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa and other inherited retinal diseases, epiretinal membrane, macular hole, retinal tears and detachment, and other conditions in which precise characterization of ocular structure and visual function is critical to evaluating disease progression and therapeutic response.

The Ophthalmology Division provides expertise across an extensive range of structural, functional, angiographic, and electrophysiologic assessments, including optical coherence tomography (OCT), color fundus photography (CFP), fundus autofluorescence (FAF), near-infrared autofluorescence, fluorescein angiography, adaptive optics retinal imaging, best-corrected visual acuity (BCVA), visual field assessments, electroretinography (ERG), full-field stimulus testing (FST), intraocular pressure (IOP), and functional MRI. Intrinsic Imaging works closely with sponsors to develop study-specific ophthalmic imaging and assessment strategies encompassing protocol development, imaging charter design, site and equipment qualification, acquisition standardization, image quality control, reader training and qualification, centralized independent review, adjudication, quantitative analysis, and regulatory-ready data delivery. Particular emphasis is placed on minimizing variability across sites, imaging systems, operators, readers, and longitudinal visits—providing the consistency and methodological rigor necessary to detect subtle anatomical and functional changes over time. By integrating ophthalmic subspecialty expertise with standardized image acquisition, sophisticated quantitative assessment, and disciplined central-review methodologies, Intrinsic Imaging provides the scientific and operational infrastructure required to support complex ophthalmology clinical development programs from early-phase investigation through pivotal trials.