Cardiology Division — Cardiac Imaging Core Lab
Intrinsic Imaging provides comprehensive cardiovascular imaging core lab services for pharmaceutical, biotechnology, and medical device clinical trials, combining subspecialty physician expertise, advanced quantitative imaging, and rigorous image management methodologies to support the evaluation of cardiovascular safety and efficacy. Our Cardiology Division brings together more than 150 board-certified, fellowship-trained cardiologists and cardiothoracic radiologists with expertise across a broad spectrum of cardiovascular and cardiopulmonary diseases, including heart failure, coronary artery disease, acute coronary syndromes, myocardial infarction, left ventricular dysfunction, valvular and structural heart disease, pulmonary arterial hypertension, peripheral vascular disease, and venous thromboembolic disease.
Intrinsic Imaging supports cardiovascular endpoints across an extensive range of imaging and diagnostic modalities, including 2D and 3D echocardiography, cardiac CT and CT angiography, cardiac MRI and MRA, adenosine stress MRI, invasive angiography, ECG, myocardial strain and speckle-tracking imaging, MUGA, PET, PET/CT, SPECT, nuclear cardiology, vascular ultrasound, and advanced thoracic imaging. Our teams work closely with sponsors from protocol development through database lock to establish standardized acquisition requirements, qualify and train imaging sites, define quantitative and qualitative assessment methodologies, conduct blinded independent central reviews, and implement adjudication procedures designed to minimize inter- and intra-reader variability. By combining cardiovascular subspecialty expertise with standardized imaging protocols, centralized quality control, and reproducible quantitative assessment, Intrinsic Imaging helps sponsors generate reliable, scientifically robust imaging data suitable for longitudinal endpoint evaluation, clinical development decision-making, and global regulatory submissions.
Cardiology Division Highlights
- Extensive experience in providing services in support of clinical trials evaluating cardiac safety and efficacy.
- +150 board certified, fellowship trained cardiologists and cardiothoracic radiologists.
- Extensive experience in cardiothoracic imaging indications.
- Focus on reducing intra-inter cardiothoracic reviewer variability.
- Modality expertise includes:
- 2D and 3D Echocardiography
- Angiography, Cardiac CTA, Cardiac MRI, Chest X-Ray
- CT, QCT, PET/CT, CR/DR, DXA
- ECG, MRA, MRI, MRE, Adenosine Stress MRI, MUGA
- Myocardial Strain imaging, Nuclear imaging
- PET, SPECT, Speckle tracking, Thoracic CT/MRI, HRCT
- Ultrasound, Vascular CTA, MRI
Cardiac Safety and Efficacy Imaging Endpoints
Our cardiac imaging core lab supports clinical trials evaluating both cardiac safety and cardiovascular efficacy. Endpoints are defined with sponsors during protocol and imaging charter development, then assessed by board-certified, fellowship-trained cardiologists and cardiothoracic radiologists using standardized quantitative and qualitative methods.
Typical assessments include left ventricular function and dysfunction, myocardial strain and speckle tracking, coronary and vascular evaluation by angiography and CTA, valvular and structural heart disease, and pulmonary and thoracic findings across heart failure, coronary artery disease, pulmonary arterial hypertension, and venous thromboembolic disease trials.
Echocardiography, Cardiac MRI and Cardiac CT Core Lab
We centrally read 2D and 3D echocardiography, cardiac MRI and MRA, adenosine stress MRI, cardiac CTA, invasive angiography, ECG, MUGA, PET, SPECT, and nuclear cardiology. Site qualification, acquisition standardization, and centralized quality control keep data consistent across sites, scanners, and longitudinal timepoints.
Blinded Independent Central Review and Adjudication
Blinded independent central review (BICR) is performed under single, double, or triple-read paradigms with adjudication procedures designed to minimize inter- and intra-reader variability, supporting reliable endpoint evaluation and global regulatory submissions.
Frequently Asked Questions
- Which cardiac imaging modalities does your core lab read?
- Echocardiography (2D/3D), cardiac MRI and MRA, stress MRI, cardiac and vascular CTA, angiography, ECG, MUGA, PET, SPECT, nuclear cardiology, ultrasound, and thoracic CT/MRI/HRCT.
- Do you support cardiac safety as well as efficacy endpoints?
- Yes. The Cardiology Division supports clinical trials evaluating both cardiac safety and cardiovascular efficacy.
- Who performs the reads?
- More than 150 board-certified, fellowship-trained cardiologists and cardiothoracic radiologists.
Planning a cardiology trial? Our sub-specialists can help.
Partner With Us